Synapse specificity of long-term potentiation breaks down with aging
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چکیده
منابع مشابه
Synapse specificity of long-term potentiation breaks down with aging.
Memory shows age-related decline. According to the current prevailing theoretical model, encoding of memories relies on modifications in the strength of the synapses connecting the different cells within a neuronal network. The selective increases in synaptic weight are thought to be biologically implemented by long-term potentiation (LTP). Here, we report that tetanic stimulation of afferent f...
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The term synaptic plasticity points to a series of persistent changes related to the activity of synapses. Long-term potentiation (LTP) is a reflection of synaptic plasticity that has an important role in learning and memory. LTP is a long-lasting increase of synaptic activity due to enhancement of excitatory synaptic transmission after a high-frequency train of electrical stimulations. Differe...
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would enable them to coopt proteins destined for other The dendrites of a typical neuron in the central nervous late LTP synaptic sites. To test this idea, a “two-pathsystem bear at least 1000 postsynaptic specializations way” experimental design was employed in which two indicating that in principal the individual neuron can independent sets of presynaptic afferents that converge process and s...
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Synaptic plasticity in the central nervous system (CNS) of mammals has been discussed for many years. Several forms of synaptic plasticity of mammal’s CNS have been identified, such as those that occur in long-term potentiation (LTP). Different types of LTP have been observed in distinctive areas of the CNS of mammals. The hippocampus is one of the most important areas in the CNS that pla...
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ژورنال
عنوان ژورنال: Learning & Memory
سال: 2007
ISSN: 1072-0502
DOI: 10.1101/lm.451507